“Manufacturing Proteins with Biomolecular Machines” by Computational Visualization Center (CVC)

  • ©  Computational Visualization Center (CVC)


SIGGRAPH Video Review:




    Manufacturing Proteins with Biomolecular Machines



Company / Institution / Agency:

  • Computational Visualization Center (CVC)


    All proteins in all cellular organisms arise through the process of translation. In this process, ribosomes (massive molecular machines) convert excerpts of the genetic code (mRNAs) into peptide chains that are subsequently folded into functionally active proteins respon-sible for executing a wide array of tasks. Past and present research has partially elucidated the complex structure and choreagraphy of the ribosome during translation. We attempt to create a biologically illuminating and visually attractive animation that incorporates current understanding of the protein synthesis process. Using e. Coli as our model, we highlight the specific nucleotides and amino acids that participate in or catalyze particular biochemical reactions.


    2 Macintosh G5s with 2 GB RAM and a Linux cluster of five machines with 1 GHz processors and 1 GB RAM


    Alias Maya, Adobe After Effects

Additional Contributors:

    Principal Investigator and Scientific Coordinator: Chandrajit Bajaj

    Visual Effects Supervisor: Rick Hankins

    Storyboard and Direction: Rick Hankins, Katherine Clarridge

    Animation and Compositing: Rick Hankins, Katherine Clarridge

    Voice Narration: Katherine Clarridge

    University of Texas-CVC Software Development Team: Vinay Siddvanahalli, Bong-Soo Sohn, John Wiggins

    Special Thanks: Jason Sun, Erin Macrorie, Jung Lee, Robin Gutell, Clarence Chan, University of Texas at Austin

    Azam Khan – Alias Systems Corporation

    Karan Singh – University of Toronto

    Stephen Sherman

    Protein Data Bank – http://www.rcsb.org/pdb/Scientists whose published work on the ribosome we could not have done this without.

    Susanne Kraft, Jeremy Gruy

    Radio Television and Film Department, University of Texas at Austin

    Supported in part by grants from National Science Foundation National Institutes of Health Alias Systems Corporation

Animation / Video Overview: